Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection.

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Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection

We have previously shown that major heat-shock protein (hsp 70) protects WEHI-S tumor cells from cytotoxicity mediated by tumor necrosis factor alpha (TNF-alpha) and TNF-beta. In the present study, the effect of altered expression of hsp70 and low molecular weight heat-shock protein, hsp27, on tumor cell sensitivity to monocytes and lymphokine-activated killer (LAK) cells was studied. Constitut...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1993

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.177.1.231